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Only three sources mentioned weight gain as a side effect of prednisone, which is just shocking to me because statistically, 70% of people on prednisone are going to gain weight. And even at low doses, we gain weight gain as possible. Prednisone Weight Gain. The one thing about weight gain is it, the higher the dose, usually the more weight Ask your provider if you should take calcium and vitamin D supplements. Long-term corticosteroid therapy may cause thinning bones, called osteoporosis. Talk Corticosteroids can cause weight gain in different ways. Corticosteroids can increase your appetite. If you feel hungrier, you may gain weight because you’re Steroids can have a significant impact on appetite. This can lead to overeating and weight gain, putting patients at greater risk for diabetes and